Within-individual genome variation and germline / soma distinction
Genomes are typically considered static/fixed across cell types and/or life stages within an organism, with changing transcriptional patterns resulting in cell differentiation and specialization. Yet, various within-individual genomic changes have been observed during development in many species across the tree of life. Such changes include ploidy variation, amplification or elimination of specific parts of the genome, and chromosome rearrangements with potentially important consequences that include cell fate, sex determination and dosage compensation as well as aging.
These data demonstrate that:
1) genomes are more dynamic than typically envisioned,
2) eukaryotes can distinguish between somatic (i.e. flexible within species) and germline (i.e. heritable) genomes, and
3) Mendelian inheritance is insufficient to explain many patterns observed across lineages.
Further, genome conflicts including those involving selfish genetic elements (i.e. transposable elements, viruses, B chromosomes), likely underlie some of these genome processes.
Combined with classic approaches such as cytogenetics and histology, emerging technologies such as single-cell and long-read sequencing now allow to study these processes at an unprecedented scale.
This symposium will bring together biologists interested in within-individual genome dynamics, with a particular emphasis on germline / soma distinction and how these processes may impact cell fate, sex determination and aging.
We hope this will help identify central questions to foster synergy and bring the field forward!
These data demonstrate that:
1) genomes are more dynamic than typically envisioned,
2) eukaryotes can distinguish between somatic (i.e. flexible within species) and germline (i.e. heritable) genomes, and
3) Mendelian inheritance is insufficient to explain many patterns observed across lineages.
Further, genome conflicts including those involving selfish genetic elements (i.e. transposable elements, viruses, B chromosomes), likely underlie some of these genome processes.
Combined with classic approaches such as cytogenetics and histology, emerging technologies such as single-cell and long-read sequencing now allow to study these processes at an unprecedented scale.
This symposium will bring together biologists interested in within-individual genome dynamics, with a particular emphasis on germline / soma distinction and how these processes may impact cell fate, sex determination and aging.
We hope this will help identify central questions to foster synergy and bring the field forward!
The Speakers
Laurence Hurst
The human early embryo is a selection arena.
Esther AngertChallenges faced by highly polyploid bacteria with limits on chromosome inheritance
Mariangela IannelloA naturally heteroplasmic clam shows the effects of genetic bottleneck on paternal mtDNA
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Marie-Julie FaveMulti-omics profiles of somatic mutations in immune cells from an aging human population
Zuzana MajtanováChromosome dynamics of sexually-parasitic, unisexual carp gudgeons (Hypseleotris)
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Christina HodsonEvolution of a germline restricted chromosome in the fungus gnat Sciara coprophila
Jeramiah SmithProgrammed Genome Rearrangement in Lamprey
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Schedule
June 29th 2020 10h00-12h30 EDT (7h00-9h30 PDT, 16h00-18h30 CEST)
Note that all times are given as Eastern Daylight Time (Quebec city time zone)
TALKS (single session)
10h00: Welcome address
10h05: Laurence Hurst + Q&A (15 min + 5 min Q/A)
10h25: short break
10h30: Esther Angert (5 min + 3 min Q/A)
10h40: Marie-Julie Favé (5 min + 3 min Q/A)
10h50: Christina Hodson (5 min + 3 min Q/A)
11h00: virtual coffee break
11h15: Mariangela Iannello (5 min + 3 min Q/A)
11h25: Zuzana Majtanová (5 min + 3 min Q/A)
11h35: Jeremiah Smith (5 min + 3 min Q/A)
POSTERS SESSIONS (multiple rooms)
11h45: virtual posters and lightning talks
(participants will be invited to visit multiple rooms, which will be organized loosely by theme)
12h25: concluding remarks
10h00: Welcome address
10h05: Laurence Hurst + Q&A (15 min + 5 min Q/A)
10h25: short break
10h30: Esther Angert (5 min + 3 min Q/A)
10h40: Marie-Julie Favé (5 min + 3 min Q/A)
10h50: Christina Hodson (5 min + 3 min Q/A)
11h00: virtual coffee break
11h15: Mariangela Iannello (5 min + 3 min Q/A)
11h25: Zuzana Majtanová (5 min + 3 min Q/A)
11h35: Jeremiah Smith (5 min + 3 min Q/A)
POSTERS SESSIONS (multiple rooms)
11h45: virtual posters and lightning talks
(participants will be invited to visit multiple rooms, which will be organized loosely by theme)
12h25: concluding remarks